Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis
M. DasGupta, D. Budday, S. H. P. de Oliveira, P. Madzelan, D. Marchany-Rivera, J. Seravalli, B. Hayes, R. G. Sierra, S. Boutet, M. Hunter, R. Alonso-Mori, A. Batyuk, J. Wierman, A. Lyubimov, A. S. Brewster, , M. A. Wilson
This study uses mix-and-inject XFEL crystallography to observe conformational changes in isocyanide hydratase during catalysis, showing how cysteine modification affects enzyme dynamics and function.
bioRxiv · Aug 24, 2019Biochemistry