Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies
R. Rouet, O. Mazigi, G. J. Walker, D. B. Langley, M. Sobti, P. Schofield, H. Lenthall, J. Jackson, S. Ubiparipovic, J. Y. Henry, A. Abayasingam, D. Burnett, A. Kelleher, R. Brink, R. A. Bull, , D. Christ
This paper explores antibody maturation strategies to enhance the neutralization of SARS-CoV-2 using SARS-CoV-1 antibodies, finding that some variants show potent neutralization with IC50 of 160 ng/ml.
bioRxiv · Dec 14, 2020Immunology