Author

D. Christ

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

P. Schofield· 4 shared R. Rouet· 4 shared D. B. Langley· 3 shared A. G. Stewart· 2 shared A. Kelleher· 2 shared H. Lenthall· 2 shared J. Jackson· 2 shared J. Y. Henry· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

P. Schofield

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Structure and dynamics of the autoantigen GAD65 in complex with the human autoimmune polyendocrine syndrome type 2-associated autoantibody b96.11

S. Stander, C. F. Reboul, S. N. Lee, D. Williams, P. G. Chandler, M. G. Costa, D. E. Hoke, J. D. Jimma, J. Fodor, G. Fenalti, S. I. Mannering, B. T. Porebski, P. Schofield, D. Christ, M. Buckle, , A. M. Buckle

This study characterizes the structure and dynamics of GAD65 and its interaction with autoantibody b96.11, revealing how intrinsic conformational flexibility drives autoantigenicity.

bioRxiv · Mar 18, 2024 · PreprintBiochemistry

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

R. Rouet, J. Y. Henry, M. D. Johansen, M. Sobti, H. Balachandran, D. B. Langley, G. Walker, H. Lenthall, J. Jackson, S. Ubiparipovic, O. Mazigi, P. Schofield, D. L. Burnett, S. H. J. Brown, M. Martinello, , D. Christ

This paper isolates broadly neutralizing SARS-CoV-2 antibodies from convalescent patients and shows they neutralize emerging variants more effectively than existing monoclonal antibodies.

bioRxiv · Oct 19, 2022Immunology

Clonal dynamics of SARS-CoV-2-specific T cells in children and adults with COVID-19

W. H. Khoo, K. Jackson, C. Phetsouphanh, J. Zaunders, J. Alquicira-Hernandez, S. Yazar, S. Ruiz-Diaz, M. Singh, R. Dhenni, W. Kyaw, F. Tea, V. Merheb, F. Lee, R. Burrell, A. Howard-Jones, , T. G. Phan

This study compares T cell responses in children and adults with mild/asymptomatic COVID-19, finding differences in T cell diversity and memory formation.

bioRxiv · Jan 30, 2022Immunology

Structure-based design of a highly stable, covalently-linked SARS-CoV-2 spike trimer with improved structural properties and immunogenicity

E. Olmedillas, C. J. Mann, W. Peng, Y.-T. Wang, R. Diaz Avalos, D. Bedinger, K. Valentine, N. Shafee, S. L. Schendel, M. Yuan, G. Lang, R. Rouet, D. Christ, W. Jiang, I. A. Wilson, , E. Ollmann Saphire

This paper designs a modified SARS-CoV-2 spike trimer, VFLIP, with enhanced stability, immunogenicity, and structural fidelity to the native spike.

bioRxiv · May 6, 2021 · PreprintMicrobiology

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

R. Rouet, O. Mazigi, G. J. Walker, D. B. Langley, M. Sobti, P. Schofield, H. Lenthall, J. Jackson, S. Ubiparipovic, J. Y. Henry, A. Abayasingam, D. Burnett, A. Kelleher, R. Brink, R. A. Bull, , D. Christ

This paper explores antibody maturation strategies to enhance the neutralization of SARS-CoV-2 using SARS-CoV-1 antibodies, finding that some variants show potent neutralization with IC50 of 160 ng/ml.

bioRxiv · Dec 14, 2020Immunology

Surface-associated antigen induces B-cell permeabilization and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

F. Y. Maeda, J. J. H. van Haaren, D. B. Langley, D. Christ, N. W. Andrews, W. Song

The paper shows surface-associated antigen induces B-cell membrane permeabilization and lysosome exocytosis, enhancing antigen uptake and T-cell presentation.

bioRxiv · Jul 24, 2020Cell Biology

PDGFR alpha signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair

N. S. Asli, M. Xaymardan, R. Patrick, N. Farbehi, J. Cornwell, E. Forte, A. J. Waardenberg, V. Janbandhu, S. Kesteven, V. Chandrakanthan, H. Malinowska, H. Reinhard, P. Schofield, D. Christ, I. Ahmed, , R. P. Harvey

This study investigates how PDGFR alpha signaling in cardiac fibroblasts affects quiescence, metabolism, and self-renewal, leading to improved heart repair after myocardial infarction.

bioRxiv · Jun 13, 2019 · PreprintCell Biology