Author

P. Schofield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

D. Christ· 4 shared A. G. Stewart· 2 shared A. Kelleher· 2 shared D. B. Langley· 2 shared H. Lenthall· 2 shared J. Jackson· 2 shared J. Y. Henry· 2 shared M. Sobti· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

D. Christ

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structure and dynamics of the autoantigen GAD65 in complex with the human autoimmune polyendocrine syndrome type 2-associated autoantibody b96.11

S. Stander, C. F. Reboul, S. N. Lee, D. Williams, P. G. Chandler, M. G. Costa, D. E. Hoke, J. D. Jimma, J. Fodor, G. Fenalti, S. I. Mannering, B. T. Porebski, P. Schofield, D. Christ, M. Buckle, , A. M. Buckle

This study characterizes the structure and dynamics of GAD65 and its interaction with autoantibody b96.11, revealing how intrinsic conformational flexibility drives autoantigenicity.

bioRxiv · Mar 18, 2024 · PreprintBiochemistry

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

R. Rouet, J. Y. Henry, M. D. Johansen, M. Sobti, H. Balachandran, D. B. Langley, G. Walker, H. Lenthall, J. Jackson, S. Ubiparipovic, O. Mazigi, P. Schofield, D. L. Burnett, S. H. J. Brown, M. Martinello, , D. Christ

This paper isolates broadly neutralizing SARS-CoV-2 antibodies from convalescent patients and shows they neutralize emerging variants more effectively than existing monoclonal antibodies.

bioRxiv · Oct 19, 2022Immunology

X-ray induced bio-acoustic emissions from cultured cells

B. Matarese, H. Rahmoune, N. Vo, C. B. Seymour, P. SCHOFIELD, C. E. Mothersill

This study records bio-acoustic emissions from X-ray irradiated cultured cells and links them to bystander effects.

bioRxiv · Jun 14, 2021Cell Biology

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

R. Rouet, O. Mazigi, G. J. Walker, D. B. Langley, M. Sobti, P. Schofield, H. Lenthall, J. Jackson, S. Ubiparipovic, J. Y. Henry, A. Abayasingam, D. Burnett, A. Kelleher, R. Brink, R. A. Bull, , D. Christ

This paper explores antibody maturation strategies to enhance the neutralization of SARS-CoV-2 using SARS-CoV-1 antibodies, finding that some variants show potent neutralization with IC50 of 160 ng/ml.

bioRxiv · Dec 14, 2020Immunology

PDGFR alpha signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair

N. S. Asli, M. Xaymardan, R. Patrick, N. Farbehi, J. Cornwell, E. Forte, A. J. Waardenberg, V. Janbandhu, S. Kesteven, V. Chandrakanthan, H. Malinowska, H. Reinhard, P. Schofield, D. Christ, I. Ahmed, , R. P. Harvey

This study investigates how PDGFR alpha signaling in cardiac fibroblasts affects quiescence, metabolism, and self-renewal, leading to improved heart repair after myocardial infarction.

bioRxiv · Jun 13, 2019 · PreprintCell Biology

Hypoxia induces rapid changes to histone methylation reprogramming chromatin for the cellular response

M. Batie, J. Frost, M. Frost, J. W. Wilson, P. Schofield, S. Rocha

The paper shows hypoxia causes rapid, HIF-independent changes in histone methylation marks, linking oxygen sensing to chromatin reprogramming for cellular response.

bioRxiv · Jan 6, 2019Biochemistry