Step-wise epigenetic signal integration governs adaptive programming of cytotoxic lymphocytes
S. Grassmann, E. K. Santosa, H. Kim, I. B. Johnson, A. M. Mujal, J.-B. LeLuduec, S. X. Fan, M. Owyong, A. Straub, L. Deng, C. M. Lau, K. Hsu, D. Busch, J. C. Sun
This study shows that interleukin-12 signaling integrates with antigen receptor signals in a context-dependent manner to determine the epigenetic and functional fate of cytotoxic lymphocytes.
bioRxiv · Nov 7, 2023 · PreprintImmunology