An Orally Available Cathepsin L Inhibitor Protects Lungs Against SARS-CoV-2-Induced Diffuse Alveolar Damage in African Green Monkeys
F. W. Frueh, D. C. Maneval, R. P. Bohm, J. P. Dufour, R. V. Blair, S. Simpson, K. Powell, P. P. Aye, N. A. Golden, C. J. ROY, S. Spencer, K. Russell-Lodrigue, K. S. Plante, J. A. Plante, J. H. McKerrow, J. Rappaport
This study shows that the orally available cathepsin L inhibitor K777 reduces SARS-CoV-2-induced lung damage in African green monkeys.
bioRxiv · Jul 20, 2021 · PreprintImmunology