P. P. Aye

This study examines how SIV-induced immunodeficiency affects SARS-CoV-2 infection in macaques, finding that while immune responses are impaired, viral kinetics and evolution remain unchanged.

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

This study shows that germinal center B cells can persist and continue to mutate for 29 weeks after a single immunization, leading to long-lasting antibody responses.

This study shows that pigtail macaques infected with SARS-CoV-2 exhibit mild-to-moderate disease with specific immune and viral dynamics, making them a potential model for studying COVID-19.

This study shows that the orally available cathepsin L inhibitor K777 reduces SARS-CoV-2-induced lung damage in African green monkeys.

This study shows that a combination of two SARS-CoV-2 neutralizing antibodies prevents COVID-19 in rhesus macaques, with full protection at a higher dose and partial protection at lower doses.

This study shows that a tyrosine-based trafficking signal in SIV Env is strongly selected for during pathogenic infection, as mutations reconstitute endocytosis and polarized sorting signals.

This study shows that ZIKV infection during pregnancy provides protection against secondary infection without relying on CD8+ cells.

This study shows that a tri-mAb cocktail of HIV envelope-specific antibodies reduces SHIV acquisition and viral loads in infant rhesus monkeys.