MOTS-c is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis
J. C. Reynolds, R. W. Lai, J. S. T. Woodhead, J. H. Joly, C. J. Mitchell, D. Cameron-Smith, R. Lu, P. Cohen, N. A. Graham, B. A. Benayoun, T. L. Merry, C. Lee
This study shows that MOTS-c, a mitochondrial-encoded peptide, improves physical performance and muscle homeostasis across ages in mice and humans, suggesting mitochondrial genes regulate aging.
bioRxiv · Dec 22, 2019Cell Biology