B. A. Benayoun

This study identifies MOTS-c, a mitochondrial-encoded host defense peptide with antibacterial and immunomodulatory functions, showing that the immune system is encoded by both nuclear and mitochondrial genomes.

The paper investigates sex-dimorphic expression of ECM genes in mouse bone marrow neutrophils using bulk and single-cell transcriptomics.

The paper shows hypoxia induces a long-lasting suppression of type I interferon and antigen presentation in breast cancer cells, enhancing metastasis and being reversible with HDACi and immunotherapy.

The paper examines aggresome formation in primary adult mouse fibroblasts across different cell-states, finding it occurs only in quiescent and immortalized cells, not in proliferating or senescent cells.

This study shows that MOTS-c, a mitochondrial-encoded peptide, improves physical performance and muscle homeostasis across ages in mice and humans, suggesting mitochondrial genes regulate aging.