A Focused Small-Molecule Screen Identifies PHA-680626 as an Amphosteric Inhibitor Disrupting the Interaction between Aurora-A and N-Myc
F. Souvalidou, D. Boi, R. Montanari, F. Polverino, G. Marini, D. Capelli, G. Pochetti, R. Contestabile, D. Trisciuoglio, A. Tramonti, P. Carpinelli, C. Ascanelli, C. Lindon, A. De Leo, R. Di Santo, , A. Paiardini
This study identifies PHA-680626 as an amphosteric inhibitor that disrupts the AURKA/N-Myc interaction, reducing N-Myc levels and cell viability in neuroblastoma cells.
bioRxiv · Mar 10, 2021 · PreprintCancer Biology