Author

C. Ascanelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

C. Lindon· 3 shared A. Paiardini· 2 shared G. Guarguaglini· 2 shared A. A. Abdelbaki· 1 shared A. De Leo· 1 shared A. Hagting· 1 shared A. M. Abdelbaki· 1 shared A. Tramonti· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

C. Lindon

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Revisiting degron motifs in human AURKA required for its targeting by APC/C-FZR1

C. Lindon, A. A. Abdelbaki, C. Ascanelli, C. Okoye, H. B. Akman, G. Janson, M.-w. Min, C. Marcozzi, A. Hagting, R. Grant, M. De Luca, I. A. Asteriti, G. Guarguaglini, A. Paiardini

This study redefines AURKA degron motifs, showing the N-terminal A-box functions as a D-box and the C-terminal D-box is not a degron but a structural motif essential for AURKA's active conformation.

bioRxiv · Jan 31, 2022Cell Biology

A Focused Small-Molecule Screen Identifies PHA-680626 as an Amphosteric Inhibitor Disrupting the Interaction between Aurora-A and N-Myc

F. Souvalidou, D. Boi, R. Montanari, F. Polverino, G. Marini, D. Capelli, G. Pochetti, R. Contestabile, D. Trisciuoglio, A. Tramonti, P. Carpinelli, C. Ascanelli, C. Lindon, A. De Leo, R. Di Santo, , A. Paiardini

This study identifies PHA-680626 as an amphosteric inhibitor that disrupts the AURKA/N-Myc interaction, reducing N-Myc levels and cell viability in neuroblastoma cells.

bioRxiv · Mar 10, 2021 · PreprintCancer Biology

Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool

R. K. Wang, C. Ascanelli, A. M. Abdelbaki, A. Y. Fung, T. Rasmusson, I. Michaelides, K. Roberts, C. Lindon

This study characterizes a PROTAC-based degrader of AURKA, showing differential targeting of subcellular AURKA pools and distinct phenotypic effects compared to traditional inhibitors.

bioRxiv · Jul 22, 2020Cell Biology