Author

S. Rinaldo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 3 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

F. Cutruzzola· 4 shared F. R. Liberati· 4 shared A. Paone· 3 shared G. Giardina· 3 shared A. Paiardini· 2 shared A. Tramonti· 2 shared G. Boumis· 2 shared R. Contestabile· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersBiochemistry

F. Cutruzzola

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

3-O-methyltolcapone and Its Lipophilic Analogues are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity

T. Poonsiri, D. dell Accantera, V. Loconte, A. Casnati, L. Cervoni, A. Arcovito, S. Benini, A. Ferrari, M. Cipolloni, E. Cacioni, F. De Franco, N. Giacche, S. Rinaldo, C. Folli, F. Sansone, , M. Cianci

This study identifies 3-O-methyltolcapone and its lipophilic analogs as potent TTR stabilizers with improved permeability and reduced toxicity compared to tolcapone.

bioRxiv · Oct 25, 2023Biochemistry

Merging Multi-OMICs with Proteome Integral Solubility Alteration Unveils Antibiotic Mode of Action

R. Maity, X. Zhang, F. R. Liberati, C. Scribani, F. Cutruzzola, S. Rinaldo, M. Gaetani, J. A. Ainsa, J. Sancho

This study introduces a multi-omics method to distinguish target-specific and off-target effects of antibiotics using proteome solubility in Helicobacter pylori.

bioRxiv · Sep 7, 2023Microbiology

THE RIBOREGULATION MECHANISM OF HUMAN SERINE HYDROXYMETHYLTRANSFERASE IS ROOTED IN AN ALLOSTERIC SWITCH

S. Spizzichino, F. Di Fonzo, C. Marabelli, A. Tramonti, A. Chaves-Sanjuan, A. Parroni, G. Boumis, F. R. Liberati, A. Paone, L. C. Montemiglio, M. Ardini, A. J. Jakobi, A. Bharadwaj, P. Swuec, G. G. Tartaglia, , F. Cutruzzola

This study identifies an allosteric RNA switch mechanism regulating SHMT1 activity, revealing structural elements critical for RNA binding and implications for RNA-based therapies.

bioRxiv · Mar 17, 2023Biochemistry

Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments

M. Monti, G. Guiducci, A. Paone, S. Rinaldo, F. R. Liberati, G. Giardina, F. Cutruzzola, G. Tartaglia

The paper models SHMT1 riboregulation to show RNA dynamically regulates serine and glycine levels, revealing RNA's role in cancer metabolism.

bioRxiv · Dec 24, 2020Biochemistry

Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex

S. Spizzichino, D. Boi, G. Boumis, R. Lucchi, F. R. Liberati, D. Capelli, R. Montanari, G. Pochetti, A. Paone, S. Rinaldo, R. Contestabile, A. Paiardini, A. Tramonti, G. Giardina, F. Cutruzzola

This study investigates the cytosolic localization and in vitro assembly of the human de novo thymidylate synthesis complex, suggesting its role extends beyond dTMP synthesis.

bioRxiv · Dec 23, 2020Biochemistry