F. Cutruzzola

This study introduces a multi-omics method to distinguish target-specific and off-target effects of antibiotics using proteome solubility in Helicobacter pylori.

This study identifies an allosteric RNA switch mechanism regulating SHMT1 activity, revealing structural elements critical for RNA binding and implications for RNA-based therapies.

The paper models SHMT1 riboregulation to show RNA dynamically regulates serine and glycine levels, revealing RNA's role in cancer metabolism.

This study investigates the cytosolic localization and in vitro assembly of the human de novo thymidylate synthesis complex, suggesting its role extends beyond dTMP synthesis.