Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
G. Minuesa, S. K. Albanese, A. Chow, A. Schurer, S.-M. Park, C. Z. Rotsides, J. Taggart, A. Rizzi, L. N. Naden, T. Chou, S. Gourkanti, D. Cappel, M. C. Passarelli, L. Fairchild, C. Adura, , M. G. Kharas
This study identifies Ro 08-2750 as a small molecule that targets MSI2 RNA-binding activity, inducing differentiation, apoptosis, and reduced disease burden in AML models.
Nature Communications · Jun 19, 2019Peer-reviewedCancer Biology