High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease
C. S. Krumm, L. Ramos-Espiritu, R. S. Landzberg…·D. E. Cohen
This study identifies small molecule inhibitors of Them1, showing they enhance fatty acid oxidation and reduce glucose production in liver cells, suggesting therapeutic potential for NAFLD.