Author

T. Chou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. A. Mistry· 2 shared A. Banerjee· 1 shared A. Chow· 1 shared A. M. Lipchik· 1 shared A. Rangarajan· 1 shared A. Rizzi· 1 shared A. Schurer· 1 shared B. S. Geller· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

B. A. Mistry

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

An acetyl-click screening platform identifies a small molecule inhibitor of Histone Acetyltransferase 1 (HAT1) with anti-tumor activity

J. J. Gruber, A. Rangarajan, T. Chou, B. S. Geller, S. Banuelos, R. Greenhouse, M. Snyder, A. M. Lipchik

This paper identifies a small molecule inhibitor of HAT1, a histone acetyltransferase, showing anti-tumor activity in vitro and in vivo.

bioRxiv · Jun 25, 2021 · PreprintBiochemistry

Xist-seeded nucleation sites form local concentration gradients of silencing proteins to inactivate the X-chromosome

Y. Markaki, J. G. Chong, C. Luong, S. Y. X. Tan, Y. Wang, E. C. Jacobson, D. Maestrini, I. Dror, B. A. Mistry, J. Schoeneberg, A. Banerjee, M. Guttman, T. Chou, K. Plath

This study identifies Xist-seeded nucleation sites that create local concentration gradients of silencing proteins, leading to X-chromosome inactivation through macromolecular crowding.

bioRxiv · Nov 22, 2020Cell Biology

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

G. Minuesa, S. K. Albanese, A. Chow, A. Schurer, S.-M. Park, C. Z. Rotsides, J. Taggart, A. Rizzi, L. N. Naden, T. Chou, S. Gourkanti, D. Cappel, M. C. Passarelli, L. Fairchild, C. Adura, , M. G. Kharas

This study identifies Ro 08-2750 as a small molecule that targets MSI2 RNA-binding activity, inducing differentiation, apoptosis, and reduced disease burden in AML models.

Nature Communications · Jun 19, 2019Peer-reviewedCancer Biology

How heterogeneous thymic output and homeostatic proliferation shape naive T cell receptor clone abundance distributions

R. Dessalles, M. D'Orsogna, T. Chou

The paper quantifies how TCR-dependent heterogeneities in proliferation and immigration rates shape naive T cell clone abundance distributions, finding proliferation heterogeneity is more important than immigration heterogeneity.

bioRxiv · Jun 19, 2019 · PreprintImmunology

The Effects of Statistical Multiplicity of Infection on Virus Quantification and Infectivity Assays

B. A. Mistry, M. R. D'Orsogna, T. Chou

The paper develops probabilistic models for statistical multiplicity of infection in virus quantification and infectivity assays and presents a web-based tool for improved parameter inference.

bioRxiv · Jun 10, 2018Biophysics