C. S. Leslie

The paper identifies a stem-like proliferative state in prostate epithelial cells driven by ERG activation, which transitions to luminal cells and is associated with specific chromatin states.

This study investigates 1D and 3D chromatin dynamics during immune memory formation in innate and adaptive lymphocytes using histone profiling, ATAC-seq, RNA-seq, and HiC.

The paper identifies a terminal differentiated subset of colonic effector Treg cells that express IL-10 and is essential for preventing intestinal inflammation.

The paper identifies six distinct synovial fibroblast states in RA driven by cytokine exposure and shows similarities to fibroblast states in other tissues.

This study uses sequential CRISPR gene editing in human iPSCs to model clonal evolution in AML, showing progressive dysplasia and identifying therapeutic vulnerabilities.

The paper develops ATAC-Array, a low-cost chromatin accessibility assay, and shows it predicts pancreatic cancer prognosis based on chromatin accessibility patterns.

This study uses single-cell RNA sequencing to identify distinct MAIT cell subtypes with different functional states during activation and infection.

This paper introduces ECLIPSE, a machine learning model that predicts essential genes and pharmacological targets in cancer by integrating genomic, cell line, and experimental features, showing better differentiation of approved cancer drugs from non-approved ones.

This study identifies Ro 08-2750 as a small molecule that targets MSI2 RNA-binding activity, inducing differentiation, apoptosis, and reduced disease burden in AML models.