PT150 is a modulator of glucocorticoid and androgen receptors with antiviral activity against SARS-CoV-2.
N. D. Theise, A. R. Arment, D. Chakravarty, J. M. H. Gregg, I. M. Jacobson, K. H. Jung, S. S. Nair, A. Tiwari, A. W. Thurston, J. Van Drie, J. B. Westover
PT150 inhibits SARS-CoV-2 with EC90 5.55 M in human bronchial epithelial cells by downregulating AR and modulating ACE2 and TMPRSS2.
bioRxiv · Jul 12, 2020Microbiology