J. Hong

Elasticity of the HIV-1 Core Facilitates Nuclear Entry and Infection

This study shows that HIV-1 core elasticity is essential for nuclear entry and infection, with capsid-targeting drugs reducing elasticity and impairing infectivity.

Mannose Supplementation Curbs Liver Steatosis and Fibrosis in Murine MASH by Inhibiting Fructose Metabolism

This study shows that mannose reduces liver steatosis and fibrosis in MASH by inhibiting fructose metabolism, offering a potential therapeutic approach.

Highly effective gene inactivation in tetraploid Xenopus laevis with low-temperature-active engineered Cas12a

This study evaluates engineered Cas12a variants for gene inactivation in Xenopus laevis, finding that Cas12a-Ultra achieves high efficiency at low temperatures.

Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22 modified FK520 analog against C. neoformans

This paper identifies a modified FK520 analog, JH-FK-08, with reduced immunosuppression and improved antifungal efficacy against C. neoformans in vivo.

Cancer cells co-evolve with retrotransposons to mitigate viral mimicry

This study shows pancreatic tumors co-evolve with retrotransposons to modulate immune responses by regulating viral mimicry through SINEs and L1 retrotransposition.

AMLs harboring DNMT3A-destabilizing variants show increased intratumor DNA methylation heterogeneity at bivalent chromatin domains

This study shows that DNMT3A-destabilizing mutations in AML increase DNA methylation heterogeneity at bivalent chromatin domains, affecting leukemic stem cell-niche interactions and drug response.

Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration

This study uses single-cell transcriptomics to analyze aging-related changes in lung regeneration and fibrosis in mice, identifying age-associated cellular and molecular alterations.

An effective sanitizer for fresh produce production: In situ plasma activated water treatment inactivates pathogenic bacteria and maintains the quality of cucurbit fruit

This paper demonstrates that plasma activated water (PAW) effectively reduces pathogenic bacteria on cucurbit fruits while maintaining quality and shelf life, outperforming sodium hypochlorite in some aspects.

Effects of breast fibroepithelial tumor associated retinoic acid receptor alpha ligand binding domain mutations on receptor function and retinoid signaling

This study examines how mutations in the RAR ligand binding domain affect retinoic acid signaling and tumorigenesis in breast fibroepithelial tumors.

Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFbeta3/TFEB/STAT3 Pathway Early during Mammary Gland Involution

The paper shows that intracellular calcium, triggered by milk stasis, activates STAT3 via SOCS3 degradation and TFEB, leading to lysosome-dependent cell death during mammary gland involution.

Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

Mitigating the Bfl-1-mediated antiapoptotic pathway in diffuse large B cell lymphoma by inhibiting HDACs

The paper withdraws due to the need for further experiments to validate conclusions about Bfl-1 and HDAC inhibition in diffuse large B cell lymphoma.

Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus

This paper develops FK506 analogs with improved fungal selectivity and antifungal efficacy, showing reduced immunosuppression and therapeutic benefit in fungal infection models.

Comparative Analysis of Right Ventricular Metabolic Reprogramming in Pre-clinical Rat Models of Severe Pulmonary Hypertension-induced Right Ventricular Failure

This study compares metabolic reprogramming in the right ventricle of two rat models of severe pulmonary hypertension-induced right ventricular failure, identifying common and distinct metabolic signatures.

MicroRNA Detection in Biological Media Using a Split Aptamer Platform

This paper develops a split aptamer platform for detecting miRNAs in biological media with high selectivity and sensitivity.

Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign

This paper redesigns an archaeal DNA polymerase to catalyze non-natural phosphoramidate linkages using structure-guided mutations.

Cooperative binding of TCR and CD4 to pMHC enhances TCR sensitivity

The paper shows CD4 enhances TCR sensitivity by forming trimolecular bonds with pMHC, which are stabilized by force and proximity.

A live attenuated influenza virus-vectored intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2 infection

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

Camel nanobodies broadly neutralize SARS-CoV-2 variants

The paper isolates two camel nanobodies that broadly neutralize SARS-CoV-2 and its variants, showing therapeutic potential in mice.

Bioactive Hydrogel Microcapsules for Guiding Stem Cell Fate Decisions by Release and Reloading of Growth Factors

This paper develops bioactive microcapsules to guide hPSC fate by releasing and reloading growth factors, reducing GF usage and improving differentiation outcomes.

The cause of on-target point mutations generated by CRISPR-Cas9 treatment in the yeast Xanthophyllomyces dendrorhous

This study identifies on-target point mutations caused by CRISPR-Cas9 in yeast, showing sequence dependence and involvement of NHEJ components.

Liposomal Dexamethasone Reduces A/H1N1 Influenza-Associated Morbidity in Mice

This study shows that liposomal dexamethasone reduces mortality and inflammation in mice infected with A/H1N1 influenza by targeting monocyte/macrophages.

A novel PD-L1-targeted shark VNAR single domain-based CAR-T strategy for treating breast cancer and liver cancer

This paper develops a PD-L1-targeted shark VNAR-based CAR-T strategy that effectively targets breast and liver cancer cells and reduces tumor metastasis in mice.

Regulatory small RNA, Qrr2, is expressed independently of sigma factor-54 and functions autonomously in Vibrio parahaemolyticus to control quorum sensing

This study identifies Qrr2 as an autonomous regulatory sRNA in Vibrio parahaemolyticus that controls OpaR independently of sigma factor-54, revealing a conserved dual-promoter mechanism for qrr2 expression.

Development of Small Molecule Inhibitors Targeting PBX1 Transcription Signaling as a Novel Cancer Therapeutic Strategy

This study develops small molecule inhibitors targeting PBX1 transcription signaling, showing they suppress cancer cell growth and re-sensitize resistant tumors.

CRTC2 regulates plasma cell metabolism and survival

This study shows that CRTC2 repression is essential for plasma cell metabolism and survival, affecting antibody production and immune response durability.

Sterilizing immunity against SARS-CoV-2 in hamsters conferred by a novel recombinant subunit vaccine

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

Resiniferatoxin (RTX) ameliorates acute respiratory distress syndrome (ARDS) in a rodent model of lung injury

This study shows that RTX reduces lung inflammation and edema in a rodent model of ALI by targeting cardiopulmonary spinal afferents.

Evolutionary Dynamics of Non-Coding Regions in Pancreatic Ductal Adenocarcinoma

This study investigates the evolutionary dynamics of non-coding regions in pancreatic cancer, finding higher mutational burden in noncoding DNA and similar mutational spectra between enhancers and coding DNA.

CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila

This study identifies METTL4 as the methyltransferase responsible for m6A methylation of U2 snRNA in Drosophila, confirming its enzymatic activity in vitro and in vivo.