A multifaceted cellular damage repair and prevention pathway promotes high level tolerance to β-lactam antibiotics
J.-H. Shin, D. Choe, B. Ransegnola, H.-R. Hong, I. Onyekwere, T. Cross, Q. Shi, B.-K. Cho, L. F. Westblade, I. Brito, T. Doerr
This study shows that the VxrAB system in Vibrio cholerae reduces β-lactam antibiotic toxicity by managing iron levels and oxidative damage, enhancing bacterial tolerance.
bioRxiv · Aug 6, 2020Microbiology