Author

T. Cross

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Organism:bacteria (other)· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

B. Ransegnola· 2 shared J.-H. Shin· 2 shared T. Dörr· 2 shared A. N. Murtha· 1 shared A. Weaver· 1 shared B.-K. Cho· 1 shared C. Fihn· 1 shared D. Choe· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

B. Ransegnola

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3 papers

Recent·Most cited

High-level carbapenem tolerance requires antibiotic-induced outer membrane modifications.

A. N. Murtha, M. I. Kazi, R. D. Schargel, T. Cross, C. Fihn, E. E. Carlson, J. M. Boll, T. Dörr

This paper identifies PhoPQ-mediated LPS modifications as a mechanism for carbapenem tolerance in Enterobacterales, showing that antibiotic-induced outer membrane changes enhance survival.

bioRxiv · Sep 25, 2021Microbiology

A multifaceted cellular damage repair and prevention pathway promotes high level tolerance to β-lactam antibiotics

J.-H. Shin, D. Choe, B. Ransegnola, H.-R. Hong, I. Onyekwere, T. Cross, Q. Shi, B.-K. Cho, L. F. Westblade, I. Brito, T. Doerr

This study shows that the VxrAB system in Vibrio cholerae reduces β-lactam antibiotic toxicity by managing iron levels and oxidative damage, enhancing bacterial tolerance.

bioRxiv · Aug 6, 2020Microbiology

Spheroplast-mediated carbapenem tolerance in Gram-negative pathogens

T. Cross, B. Ransegnola, J.-H. Shin, A. Weaver, K. Fauntleroy, M. VanNieuwenhze, L. Westblade, T. Dörr

This study shows that several Gram-negative pathogens exhibit carbapenem tolerance through cell wall-deficient spheroplasts, which can recover upon antibiotic removal.

bioRxiv · Mar 15, 2019Microbiology