Functional impairment of "helpless" CD8+ memory T cells is transient and driven by prolonged but finite cognate antigen presentation
V. van der Heide, B. Davenport, B. Cubitt, V. Roudko, D. Choo, E. Humblin, K. Jhun, K. Angeliadis, T. Dawson, G. Furtado, A. O. Kamphorst, R. Ahmed, J. C. de la Torre, D. Homann
This study shows that helpless CD8+ memory T cells, which form without CD4+ help, have transient functional impairments due to prolonged antigen exposure, which resolve over time.
bioRxiv · Jan 22, 2024Immunology