V. van der Heide

This study shows that helpless CD8+ memory T cells, which form without CD4+ help, have transient functional impairments due to prolonged antigen exposure, which resolve over time.

This study examines ACE2 and SARS-CoV-2 expression in normal and COVID-19 pancreas tissues, finding prominent ACE2 expression in ductal epithelium and microvasculature, with limited endocrine cell expression and no strong evidence of SARS-CoV-2 infection of endocrine cells.

This study defines the chemokine profiles of pathogen-specific effector T cells and identifies their temporospatial organization and regulatory mechanisms.

This study shows that aging enhances CD8+ memory T cell recall responses by utilizing diverse molecular mechanisms, supporting the rebound model of immune memory.

This study shows that aging of antiviral CD8+ memory T cells leads to increased survival, metabolic adaptations, and lymphoid tissue homing, enhancing their recall response capabilities.