Aspergillus-mediated allergic airway inflammation is triggered by dendritic cell recognition of a defined spore morphotype, a process that can be targeted via antifungal therapeutics.
E. L. Houlder, S. Gago, G. Vere, D. Conn, S. Khan, D. Thomson, M. Shepherd, R. Lebedinec, G. D. Brown, M. Bromley, A. S. MacDonald, P. C. Cook
This study identifies a specific stage of Aspergillus fumigatus spore development that activates dendritic cells to trigger allergic airway inflammation and shows antifungal drugs can reduce this process.
Journal of Allergy and Clinical Immunology · Mar 1, 2025Peer-reviewedImmunology