S. Gago

Aspergillus-mediated allergic airway inflammation is triggered by dendritic cell recognition of a defined spore morphotype, a process that can be targeted via antifungal therapeutics.

This study identifies a specific stage of Aspergillus fumigatus spore development that activates dendritic cells to trigger allergic airway inflammation and shows antifungal drugs can reduce this process.

A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis

The paper identifies conidial surface proteins in Aspergillus fumigatus and shows their role in immune evasion during infection.

Mycobiome analyses of critically ill COVID-19 patients

This study analyzes the respiratory mycobiome of critically ill COVID-19 patients to identify fungal signatures linked to mortality and antifungal drug use.

COVID-19 Associated Pulmonary Aspergillosis isolates are genomically diverse but similar to each other in their responses to infection-relevant stresses

This study analyzes 11 Aspergillus fumigatus isolates from COVID-19 patients with pulmonary aspergillosis, finding genomic diversity but similar stress responses to infection.

Aspergillus fumigatus can display persistence to the fungicidal drug voriconazole

This study shows that some Aspergillus fumigatus isolates can persist in the presence of voriconazole, a fungicidal drug, and this persistence is associated with a distinct transcriptional profile and reduced treatment efficacy.

Mutual inhibition of airway epithelial responses supports viral and fungal co-pathogenesis during coinfection

This study shows that viral and fungal infections inhibit each other's clearance by airway epithelial cells during coinfection, promoting disease severity.