D. Thomson

Aspergillus-mediated allergic airway inflammation is triggered by dendritic cell recognition of a defined spore morphotype, a process that can be targeted via antifungal therapeutics.

This study identifies a specific stage of Aspergillus fumigatus spore development that activates dendritic cells to trigger allergic airway inflammation and shows antifungal drugs can reduce this process.

Targeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence

This paper identifies methionine synthase as a promising antifungal target by showing its essentiality in Aspergillus fumigatus and validates its druggability using a genetic model of established infections.

Characterization of apo-form selective inhibition of indoleamine 2,3-dioxygenase.

This study compares two IDO1 inhibitors, showing GSK5628 selectively inhibits apo-IDO1 by competing with heme, while epacadostat binds to the heme cofactor, leading to longer-lasting inhibition.

Proteome thermal stability reflects organ physiology and identifies drug-target engagement in vivo

This study introduces tissue-TPP and blood-CETSA to measure proteome thermal stability, revealing organ physiology and drug-target engagement in vivo.