Matched three-dimensional organoids and two-dimensional cell lines of melanoma brain metastases mirror response to targeted molecular therapy
W. H. Hicks, L. C. Gattie, J. I. Traylor, D. Davar, Y. G. Najjar, T. E. Richardson, S. K. McBrayer, K. G. Abdullah
This study develops matched patient-derived organoids and cell lines from melanoma brain metastases to evaluate responses to targeted therapies, finding both models respond to BRAF and MEK inhibitors.
bioRxiv · Jan 18, 2024Cancer Biology