K. Smith

Identification of distinct genotypes in circulating RSV A strains based on variants on the virus replication-associated genes

The paper identifies distinct genotypes in RSV A strains by analyzing variants in replication-associated genes from sequenced samples and highlights the polymerase protein L as a robust genotyping target.

Convergent evolution of complex adaptive traits enabled human life at high altitudes

The paper shows that high-altitude Andean populations experienced selective events at angiogenic pathways, similar to Himalayan populations, despite partial gene-level convergence.

Identification of tumor-intrinsic drivers of immune exclusion in acral melanoma

This study identifies 11 oncogenic pathways associated with immune exclusion and ICI resistance in acral melanoma, suggesting therapeutic targets for immunotherapy combinations.

AlphaFold2 modeling and molecular dynamics simulations of an intrinsically disordered protein

The paper uses AlphaFold2 and molecular dynamics simulations to model an intrinsically disordered protein, showing that its conformations are more variable compared to well-folded proteins.

Adaptive therapy achieves long-term control of chemotherapy resistance in high grade ovarian cancer

This study demonstrates that adaptive therapy reduces chemotherapy resistance in ovarian cancer by exploiting fitness costs of resistant cells, extending survival in mice and correlating with disease burden in patients.

FUME-TCRseq: Sensitive and accurate sequencing of the T-cell receptor from limited input of degraded RNA

FUME-TCRseq is a sensitive and accurate method for TCR sequencing from low-quality RNA, outperforming existing methods in detecting clonotypes and enabling analysis of archival tissue samples.

Measuring and Modeling Macrophage Growth using a Lab-on-CMOS Capacitance Sensing Microsystem

The paper uses a lab-on-CMOS biosensor to track macrophage growth and develops a temporal model to describe growth kinetics over 30 hours.

Inter-species stimulus enhancement: Herring gulls (Larus argentatus) read human behaviour during foraging

This study shows herring gulls use human cues to enhance foraging by directing attention to food items matching the demonstrator's actions.

Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming

This study shows that PLA degradation products reprogram cell metabolism, leading to immune activation and inflammation, and demonstrates that targeting metabolism can reduce inflammation and improve biocompatibility.

Mapping multiregional imaging-localized biopsies to MRI habitats reveals biologically significant glioma tissue states and associated patterns of cohabitating cellular subpopulations

The paper maps MRI-localized glioma biopsies to MRI habitats, identifying transcriptional tissue states and their association with cellular subpopulations and MRI features.

Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh Syndrome

This study shows acarbose reduces symptoms and improves survival in a mouse model of Leigh Syndrome, independent of mTOR inhibition, and suggests gut microbiome modulation may impact mitochondrial disease.

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

Muscle activation strategies of the vastus lateralis according to sex

This study compares neuromuscular recruitment strategies in men and women during isometric contractions, finding women use smaller motor units with higher firing rates while both sexes show similar force production strategies.

Effects of High-Volume versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations

This study compares high-volume and high-load resistance training on muscle growth and molecular markers, finding similar hypertrophic and strength adaptations despite differences in protein synthesis rates.

Muscle-specific Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

This study identifies Cavin4's role in T-tubule formation and stability in skeletal muscle by showing its interaction with Bin1 and effects on caveolae remodeling.

Cooperative Communication with Humans Evolved to Emerge Early in Dogs

This study compares dog and wolf puppies to show domestication enhanced dogs' cooperative communication with humans through increased attraction to humans.

A novel female-specific circadian clock mechanism regulating metabolism

This study identifies a female-specific circadian clock mechanism involving Siah2 that regulates metabolic rhythms and gene expression in the liver.

Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin

This study identifies a small molecule that stabilizes Z α1-antitrypsin, reduces polymerization, and increases its secretion in cells and mice.

Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response

The paper shows mitochondria form contact sites with the nucleus to facilitate a pro-survival retrograde response by stabilizing transcription factors like NF-kB.

JAK1 inhibition blocks lethal sterile immune responses:implications for COVID-19 therapy

JAK1 inhibition prevents lethal immune responses and organ failure in a mouse model of Down syndrome and viral infection.

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

A role for the VPS retromer in Brucella intracellular replication revealed by genome-wide siRNA screening

This study identifies the VPS retromer as a critical host factor required for Brucella to escape lysosomal degradation and establish its replicative niche through a genome-wide siRNA screen.

Enabling Precision Medicine via standard communication of NGS provenance, analysis, and results

The paper introduces the BioCompute framework to standardize genomic data reporting, enabling reproducibility and interoperability in precision medicine.

Baseline human gut microbiota profile in healthy people and standard reporting template

The paper establishes a baseline human gut microbiota profile and provides a reference database and reporting tool for clinical and research applications.

Cdt1 modulates kinetochore-microtubule attachment stabilization via an Aurora B kinase-dependent mechanism

This paper shows Cdt1 binds microtubules and its phosphorylation by Aurora B kinase affects kMT stability and mitotic progression.

Hunter-gatherers maintain assortativity in cooperation despite high-levels of residential change and mixing

The paper examines cooperation patterns in Hadza hunter-gatherers, finding that despite high residential mixing, cooperation remains assortative, driven by social norms and campmate behavior rather than stable individual traits.

Phylogenetic analysis of West Nile Virus in Maricopa County, Arizona: Evidence for dynamic behavior of strains in two major lineages in the American Southwest

The paper analyzes WNV strains in Maricopa County, Arizona, showing two major lineages with dynamic behavior, including local overwintering of NA/WN02 strains.