Author

D. de Groot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

B. Morris· 1 shared C. F. Ramirez· 1 shared C. Gobel· 1 shared D. J. Kloosterman· 1 shared D. Taranto· 1 shared E. Kasa· 1 shared E. Tsouri· 1 shared F. van Leeuwen· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

B. Morris

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Author profile →

2 papers

Recent·Most cited

Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B Cell Lymphoma

C. Gobel, R. Niccholai, M. H. P. de Groot, J. Jayachandran, J. J. H. Traets, B. Morris, J.-Y. Song, L. Azarang, E. Kasa, D. de Groot, M. Kreft, M. J. Kersten, M. A. Aslam, F. van Leeuwen, H. Jacobs

This study shows that targeting DOT1L and EZH2 together disrupts the germinal center identity of GCB-DLBCL cells, leading to a cell-identity crisis and reduced tumor growth in vivo.

bioRxiv · Jun 5, 2024Cancer Biology

Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma

C. F. Ramirez, D. Taranto, M. Ando-Kuri, M. H. de Groot, E. Tsouri, Z. Huang, D. de Groot, R. J. Kluin, D. J. Kloosterman, J. Verheij, J. Xu, S. Vegna, L. Akkari

This study identifies how cancer genetics shape the tumor microenvironment in hepatocellular carcinoma, revealing myeloid cell-specific vulnerabilities that can be targeted with GM-CSF inhibition.

bioRxiv · Oct 29, 2023Cancer Biology