H. Jacobs

Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B Cell Lymphoma

This study shows that targeting DOT1L and EZH2 together disrupts the germinal center identity of GCB-DLBCL cells, leading to a cell-identity crisis and reduced tumor growth in vivo.

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

This study uses an in situ lineage tracing method to show that aging increases the number of HSPCs contributing to myelopoiesis, not their individual output.

BACE1, but not BACE2, function is critical for metabolic disorders induced by high-fat diets in C57BL/6N mice

This study shows that BACE1, but not BACE2, knockout improves metabolic outcomes in mice on a high-fat diet, suggesting BACE1 inhibition may enhance metabolic homeostasis.

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation

This study identifies DOT1L as a key regulator of B cell differentiation by controlling epigenetic programs that maintain B cell naivety and support germinal center formation.

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells

This study shows that DOT1L prevents premature differentiation of CD8+ T cells and maintains their epigenetic identity, independent of antigen exposure.

Senolytic treatment targets aberrant p21-expression to restore liver regeneration in adult mice

This study shows that senolytic drugs improve liver regeneration in adult mice by targeting aberrant p21 expression, while p16Ink4a expression remains unaffected.

Evolutionarily-conserved chromatin crosstalk generates a DOT1L-dose dependency in thymic lymphoma caused by loss of HDAC1

The paper identifies an evolutionarily-conserved interaction between HDAC1 and DOT1L that influences H3K79 methylation and contributes to thymic lymphoma development.

Mitochondria Are Physiologically Maintained At Close To 50 °C

The paper measures mitochondrial temperature in situ and finds it can exceed 50°C under physiological conditions, influenced by respiratory chain activity and thermogenic enzymes.