Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
Y. Lu, T. Cho, S. Mukherjee, A. A. Malik, N. Gonzalez-Foutel, C. F. Suarez, D. Derovic, R. H. Oh, E. Langille, K. Al-Zahrani, Z. Lin, R. Tsai, V. Rotter, P. Ashton-Prolla, L. B. Chemes, , D. Schramek
This study uses CRISPR screens to identify factors regulating wild-type and mutant p53 stability, finding distinct regulators for different p53 mutants and their implications in cancer.
bioRxiv · Mar 13, 2022Cancer Biology