A.-C. Gingras

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2

This study identifies α-catenin mechanosensitivity as a driver of cytokinesis failure through sequestration of LZTS2, linking it to polyploidization and retinal dystrophy.

Systematic profiling of the acetyl lysine machinery reveals a role for MAPKAPK2 in bromodomain inhibitor resistance

This study maps the acetyl lysine machinery interactions and identifies MAPKAPK2 as a factor contributing to resistance to BET bromodomain inhibitors in melanoma.

Spatial proteomic mapping of human nuclear bodies reveals new functional insights into RNA regulation

The paper maps human nuclear bodies using proximity proteomics, identifying new components and regulatory functions in RNA regulation.

mRNA Vaccine-Induced SARS-CoV-2 Spike-Specific IFN-γ and IL-2 T-cell Responses are Predictive of Serological Neutralization and are Transiently Enhanced by Pre-Existing Cross-Reactive Immunity

This study examines how mRNA vaccine-induced T-cell responses correlate with neutralizing antibodies and how pre-existing immunity affects vaccine responses over time.

Control of GSK3beta nuclear localization by amino acid signaling requires GATOR1 but is mTORC1 independent

The paper shows that GATOR1 regulates GSK3β nuclear localization in response to amino acids, independent of mTORC1, and that this process supports cell survival under metabolic stress.

Repression of mRNA translation initiation by GIGYF1 via blocking the eIF3-eIF4G1 interaction

This study identifies GIGYF1 as a repressor of mRNA translation by disrupting the eIF3-eIF4G1 interaction, enhancing host immune response by derepressing Ifnb1 mRNA.

Pervasive mislocalization of pathogenic coding variants underlying human disorders

The paper develops a high-throughput imaging platform to assess the functional impact of missense variants on protein localization, finding that mislocalization is common in pathogenic variants.

Immunogenicity of COVID-19 vaccines and their effect on the HIV reservoir in older people with HIV

This study evaluates the immunogenicity of COVID-19 vaccines in older people with HIV and their impact on HIV reservoirs, finding that three doses are needed for optimal neutralizing responses but vaccines may increase HIV reservoirs in those with persistent viremia.

Functional diversification despite structural congruence in the HipBST toxin-antitoxin system of Legionella pneumophila

This study characterizes a conserved TA system in Legionella pneumophila, showing functional divergence from its E. coli counterpart despite structural similarity.

SLC3A2 N-glycosylation and alternate evolutionary trajectories for amino acid metabolism

This study investigates how N-glycosylation sites on SLC3A2 evolve and regulate amino acid transport and redox balance, revealing their role in cellular trafficking and bird evolution.

ESYT1 tethers the endoplasmic reticulum to mitochondria and is required for mitochondrial lipid and calcium homeostasis

This study identifies ESYT1 as a key protein tethering ER and mitochondria at MERCs, showing its role in calcium and lipid homeostasis.

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 using Proximity Labeling and Affinity Purification

This study maps the human SLX4 interactome using BioID and AP-MS, identifying 237 high-confidence interactors and revealing new pathways involved in DNA repair and other cellular processes.

Calcineurin associates with centrosomes and regulates cilia length maintenance

This study identifies calcineurin's association with centrosomes and its role in regulating cilia length maintenance through interaction with POC5.

The L. pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4-NOT

This study shows that the L. pneumophila effector PieF interacts with the CCR4-NOT complex to modulate mRNA stability and expression.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

This study uses CRISPR screens to identify factors regulating wild-type and mutant p53 stability, finding distinct regulators for different p53 mutants and their implications in cancer.

Longitudinal Assessment of SARS-CoV-2 Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multi-Cytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity

This study tracks SARS-CoV-2-specific T cell cytokine responses over one year, finding persistent multi-cytokine production with greater immunity linked to disease severity.

Immunogenicity of convalescent and vaccinated sera against clinical isolates of ancestral SARS-CoV-2, beta, delta, and omicron variants

The paper assesses neutralizing antibody responses of convalescent and vaccinated sera against SARS-CoV-2 ancestral, beta, delta, and omicron variants.

CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7

The paper uses cryoEM to study endogenous V-ATPase interactions with mEAK-7 in porcine kidney, revealing structural insights and functional differences compared to yeast.

Mutated in Colorectal Cancer (MCC): a centrosomal protein that relocalizes to the ncMTOC during intestinal cell differentiation

This study investigates the subcellular localization of MCC in the intestinal epithelium, showing its role in centrosomal and ncMTOC dynamics during differentiation.

Palmitoylation targets the Calcineurin phosphatase to the Phosphatidylinositol 4-kinase complex at the plasma membrane

This study identifies palmitoylation as a mechanism that localizes CNA{beta}1 to the plasma membrane and Golgi, enabling its interaction with the PI4KA complex and regulating PI4P production.

Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B

This paper evaluates a SARS-CoV-2 mRNA vaccine, PTX-COVID19-B, showing it is safe, effective, and induces strong immune responses in mice and hamsters, with ongoing human clinical trials.

Rag GTPases and Phosphatidylinositol 3-Phosphate Mediate Recruitment of the AP-5/SPG11/SPG15 Complex

The paper shows that AP-5/SPG11/SPG15 complex recruitment to late endosomes/lysosomes requires PI3P and Rag GTPases, linking it to mTORC1 pathway and autophagic lysosome reformation.

TAZ-CAMTA1 and YAP-TFE3 modulate the basal TAZ/YAP transcriptional program by recruiting the ATAC histone acetyltransferase complex

This study identifies the ATAC histone acetyltransferase complex as an oncogenic driver in EHE by showing TAZ-CAMTA1 and YAP-TFE3 recruit it to modulate transcription and chromatin structure.

A SARS-CoV-2 BioID-based virus-host membrane protein interactome and virus peptide compendium: new proteomics resources for COVID-19 research

The paper uses BioID and mass spectrometry to identify SARS-CoV-2-host membrane protein interactions and virus peptides, providing new proteomics resources for COVID-19 research.

A simple protein-based surrogate neutralization assay for SARS-CoV-2

The paper introduces a protein-based assay to detect neutralizing antibodies against SARS-CoV-2, showing it correlates with traditional viral neutralization tests.

A high-density human mitochondrial proximity interaction network.

This paper creates a high-resolution human mitochondrial proximity interaction network using BioID, identifying 1465 proteins and 15626 interactions, revealing sub-compartment organization and functional modules.

Systematic discovery of Short Linear Motifs decodes calcineurin phosphatase signaling

The paper identifies calcineurin (CN) substrates and interactors using a combination of experimental and computational methods, revealing novel roles for CN in regulating nuclear pore complex proteins.

Endogenous BioID elucidates TCF7L1 interactome modulation upon GSK-3 inhibition in mouse ESCs

The paper uses BioID to study TCF7L1 interactome changes in mouse ESCs with GSK-3 inhibition, identifying new interactors and showing increased detection with reduced BirA*-TCF7L1 levels.

Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins

The paper characterizes RhoGEF/RhoGAP substrate specificities, localization, and interactomes to reveal their role in spatially organizing Rho signaling.

The endosomal sorting adaptor HD-PTP is required for ephrin-B:EphB signalling in cell collapse and motor axon guidance

This study identifies HD-PTP as an ESCRT adaptor required for ephrin-B:EphB signalling, affecting cell collapse and axon guidance by modulating receptor clustering and degradation.