Z. Lin

An Unbiased Proteomic Platform for ATE1-based Arginylation Profiling

The paper introduces an unbiased proteomic platform for ATE1-based arginylation profiling, identifying 235 unique arginylation sites in human proteomes.

Mechanism-guided engineering of a minimal biological particle for genome editing

This study engineers a minimal EDV for genome editing by removing viral components, showing improved efficiency and reduced size.

Conditioned immunological memory: implication for cognition of immune cells

This study demonstrates that immune cells can undergo classical conditioning, forming associations between hapten analogues and conjugates, leading to conditioned immunological memory and humoral immunosuppression.

Early-life Microbiome-Derived HCA Enhances Type 3 Immunity via FXR-dependent m6A RNA methylation

A safe and effective method for thin cornea cross-linking

This paper introduces a new corneal cross-linking method using photo-initiators and visible blue light, which is safer and more effective for thin corneas than the standard riboflavin/UVA protocol.

Dynamic Tumor Immune Microenvironment Remodeling Predicts Response of Checkpoint Inhibitor Therapy

The paper maps treatment-associated changes in the tumor immune microenvironment using single-cell RNA sequencing and identifies transition patterns that predict response to checkpoint inhibitor therapy.

Brain implantation of tissue-level-soft bioelectronics 1 via embryonic development

This paper introduces a stretchable microelectrode array that integrates into the developing brain, enabling long-term, stable neural activity tracking without disrupting development.

Interpretable Protein-DNA Interactions Captured by Structure-Sequence Optimization

The paper introduces IDEA, a model that predicts DNA recognition sites and binding affinities using structure-sequence optimization, enabling physicochemical interpretation of protein-DNA interactions.

Anatomics MLT, an AI tool for large scale quantification of ultrastructural traits

The paper develops an AI tool for quantifying ultrastructural traits from 3D microscopic datasets and improves fixation protocols for plants.

Topoisomerase I is an Evolutionarily Conserved Key Regulator for Satellite DNA Transcription

This study identifies Topoisomerase I as a conserved regulator of satellite DNA transcription across species, showing its role in centromere function and DNA damage response.

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

This paper develops a nanocluster-antibody-drug conjugate (NADC) for interstitial cystitis, showing it targets NGF-overexpressing bladder lesions and reduces inflammation in rat models.

Soluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay

The paper shows soluble β-tubulins sequester TTC5 to regulate tubulin mRNA decay, with loss of sequestration leading to reduced mRNA levels and chromosome segregation defects.

SwinCell: a transformer-based framework for dense 3D cellular segmentation

SwinCell is a 3D transformer-based framework that improves segmentation of dense cellular images by balancing local feature recognition and contextual understanding.

Cyborg islets: implanted flexible electronics reveal principles of human islet electrical maturation

The paper uses flexible electronics to study electrical maturation of human pancreatic islets over time, identifying key electrical states and their role in hormone secretion.

Chromosome-level Subgenome-aware de novo Assembly of Saccharomyces bayanus Provides Insight into Genome Divergence after Hybridization

This study assembles the chromosome-level genome of Saccharomyces bayanus and compares it to its parental species to understand genome divergence after hybridization.

Development and application of GlycanDIA workflow for glycomic analysis

The paper develops GlycanDIA, a DIA-based workflow for glycan identification and quantification, showing improved sensitivity and the ability to detect low-abundant modified glycans.

Deep Plasma Proteome Profiling by Modulating Single Nanoparticle Protein Corona with Small Molecules

This paper demonstrates that adding small molecules to plasma enhances nanoparticle protein corona diversity, significantly increasing the number of detectable proteins in plasma proteome profiling.

Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma.

This paper develops a tri-modular CAR T cell construct with a dominant-negative TGF-β receptor II to overcome GBM resistance by enhancing T cell function and efficacy in a preclinical model.

Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

This study uses scRNA-seq to analyze how chemotherapy remodels the immune landscape and metabolic state in lung adenocarcinoma, identifying changes in macrophage subtypes and immune responses.

Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to GDNF secretion

This study shows neurons enhance blood-brain barrier function by increasing claudin-5 and VE-cadherin via GDNF secretion and develops a triple co-culture model to predict BBB permeability.

A Novel Therapeutic Approach using CXCR3 Blockade to Treat Immune Checkpoint Inhibitor-mediated Myocarditis

This study identifies CXCR3-CXCL9/10 axis as a therapeutic target for ICI-mediated myocarditis using mouse models and human patient data.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

Un1Cas12f1 and Cas9 gene drive in HSV1: Viruses that 'infect' viruses

This study develops Cas9 and Un1Cas12f1 gene drives in HSV1 to assess gene drive efficacy and resistance, finding Un1Cas12f1 has higher conversion and lower resistance.

Multi-scale photocatalytic proximity labeling reveals cell surface neighbors on and between cells

The paper introduces a multi-scale proximity labeling method using Eosin Y to map cell surface protein neighborhoods at varying resolutions and validates interactions of EGFR and CAR-T cell synapses.

Transcriptional coupling of telomeric retrotransposons with the cell cycle

This study identifies Mediator complex subunits, Scalloped, and E2F1-Dp as regulators of telomeric retrotransposon transcription and telomere length in Drosophila, linking TR expression to the cell cycle.

A muscle hypertrophy-derived myokine reprograms the stromal vascular fractions differentiation towards thermogenic adipocytes in subcutaneous adipose tissue

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

SMB controls decompartmentalization in Arabidopsis root cap cells to execute programmed cell death

The paper identifies SMB-controlled decompartmentalization events and ion fluxes in Arabidopsis root cap cells that execute programmed cell death.

Correlative single-cell hard X-ray tomography and X-ray fluorescence imaging

This paper develops a method to combine single-cell X-ray tomography and fluorescence imaging to study cellular structures and chemical element distributions.

Immuno-Engineered Mitochondria for Efficient Therapy of Acute Organ Injuries via Modulation of Inflammation and Cell Repair

This study develops nMITO, engineered mitochondria that target inflammation and repair in acute organ injuries, showing efficacy in mouse models of myocardial, liver, and pancreatitis injuries.

Disulfiram Exerts anti-pulmonary Fibrosis Effect by Activating PGE2 Synthesis

This study shows that Disulfiram reduces pulmonary fibrosis by reactivating COX-2-mediated PGE2 synthesis in both cell and animal models.