Hypoxia-Induced PIM Kinase and Laminin-Activated Integrin α6 Mediate Resistance to PI3K Inhibitors in Bone-Metastatic CRPC
R. Toth, J. Tran, M. Muldong, E. Nollet, V. Schulz, C. Jensen, L. Hazelhurst, E. Corey, D. Durden, C. Jamieson, C. Miranti, N. Warfel
The paper identifies two survival pathways in bone-metastatic CRPC that confer resistance to PI3K inhibitors and shows combined inhibition of integrin α6β1 and PIM kinase is needed to overcome this resistance.
bioRxiv · Jun 27, 2019 · PreprintCancer Biology