C. Jensen

Collagen type I promotes pancreatic tumor growth and limits immune cell infiltration

This study shows that collagen type I promotes pancreatic tumor growth and limits immune cell infiltration in mice, supported by human dataset analysis.

Robust control of replication initiation in the absence of DnaA-ATP {leftrightharpoons} DnaA-ADP regulatory elements in Escherichia coli

The paper investigates the role of DnaA-ATP/ADP conversion in E. coli replication initiation, finding that intrinsic ATPase activity alone can maintain robust initiation, with regulatory elements enhancing stability during multifork replication.

A pandemic clonal lineage of the wheat blast fungus

The paper identifies a pandemic clonal lineage of the wheat blast fungus that originated in South America and spread to Asia and Africa, showing it can be controlled by Rmg8 but may develop fungicide resistance and recombine with African lineages.

Transcriptional dynamics of methane-cycling microbiomes are linked to seasonal CH4 fluxes in two hydromorphic and organic-rich grassland soils

The paper links methane-cycling microbiome transcriptional dynamics to seasonal CH4 fluxes in two grassland soils using quantitative metatranscriptomics.

Development of a Coronavirus Disease 2019 Nonhuman Primate Model Using Airborne Exposure

This study infects nonhuman primates with SARS-CoV-2 via airborne exposure and compares disease progression across species.

The Sle1 Cell Wall Amidase Controls Daughter Cell Splitting, Cell Size, and β-Lactam Resistance in Community Acquired Methicillin Resistant Staphylococcus aureus USA300

This study identifies Sle1 as a key factor in β-lactam resistance in MRSA USA300, showing that high Sle1 levels promote cell separation and reduce oxacillin sensitivity.

Hypoxia-Induced PIM Kinase and Laminin-Activated Integrin α6 Mediate Resistance to PI3K Inhibitors in Bone-Metastatic CRPC

The paper identifies two survival pathways in bone-metastatic CRPC that confer resistance to PI3K inhibitors and shows combined inhibition of integrin α6β1 and PIM kinase is needed to overcome this resistance.

N-terminal β-strand underpins biochemical specialization of an ATG8 isoform

The paper identifies the N-terminal β-strand and a single amino acid polymorphism as key determinants of binding specificity for the ATG8 isoform in potato, shaping interactions with PexRD54 and other plant proteins.

The ClpX chaperone controls the Staphylococcus aureus cell cycle but can be bypassed by β-lactam antibiotics

This paper shows that β-lactam antibiotics can bypass the growth defect of S. aureus clpX mutants by restoring septum synthesis and preventing premature cell lysis.