Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation
L. A. Gruijs da Silva, F. Simonetti, S. Hutten, H. Riemenschneider, E. L. Sternburg, L. M. Pietrek, J. Gebel, V. Doetsch, D. Edbauer, G. Hummer, L. S. Stelzl, D. Dormann
This study shows that hyperphosphorylation of TDP-43 reduces its phase separation and aggregation, suggesting it may act as a protective mechanism against neurodegeneration.
bioRxiv · Apr 30, 2021Biochemistry