Author

F. Simonetti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

A.-E. Lehesjoki· 1 shared C. Jackson· 1 shared D. Dormann· 1 shared D. Edbauer· 1 shared E. Daura· 1 shared E. L. Sternburg· 1 shared G. Hummer· 1 shared H. Riemenschneider· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperPathology

A.-E. Lehesjoki

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation

L. A. Gruijs da Silva, F. Simonetti, S. Hutten, H. Riemenschneider, E. L. Sternburg, L. M. Pietrek, J. Gebel, V. Doetsch, D. Edbauer, G. Hummer, L. S. Stelzl, D. Dormann

This study shows that hyperphosphorylation of TDP-43 reduces its phase separation and aggregation, suggesting it may act as a protective mechanism against neurodegeneration.

bioRxiv · Apr 30, 2021Biochemistry

Ectopic histone clipping in the mouse model of progressive myoclonus epilepsy

E. Daura, S. Tegelberg, M. Yoshihara, C. Jackson, F. Simonetti, K. Aksentjeff, S. Ezer, P. Hakala, S. Katayama, J. Kere, A.-E. Lehesjoki, T. Joensuu

This study identifies CSTB as a regulator of histone H3 tail clipping in NPCs and links its deficiency to epigenetic dysregulation and impaired mitochondrial function in a mouse model of progressive myoclonus epilepsy.

bioRxiv · Aug 21, 2020 · PreprintPathology