Author

V. Doetsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

F. Loehr· 3 shared A. Stolz· 2 shared G. Hummer· 2 shared J. Gebel· 2 shared S. Knapp· 2 shared A. Balakrishnan· 1 shared A. C. Ravicahandran· 1 shared A. Chaikuad· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

F. Loehr

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways

R. Berkane, H. Ho-Xuan, M. Glogger, P. Sanz-Martinez, L. Brunello, T. Glaesner, S. K. Kuncha, K. Holzhueter, S. Cano-Franco, V. Buonomo, P. Cabrerizo-Poveda, A. Balakrishnan, M. Misra, T. Juretschke, K. Husnjak, , A. Stolz

This study identifies CK2-dependent phosphorylation and ubiquitination as essential for FAM134B and FAM134C-driven ER-phagy activation during mTOR inhibition.

bioRxiv · Feb 27, 2023Cell Biology

Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation

L. A. Gruijs da Silva, F. Simonetti, S. Hutten, H. Riemenschneider, E. L. Sternburg, L. M. Pietrek, J. Gebel, V. Doetsch, D. Edbauer, G. Hummer, L. S. Stelzl, D. Dormann

This study shows that hyperphosphorylation of TDP-43 reduces its phase separation and aggregation, suggesting it may act as a protective mechanism against neurodegeneration.

bioRxiv · Apr 30, 2021Biochemistry

Design, Synthesis and Evaluation of WD-repeat containing protein 5 (WDR5) degraders

A. Doelle, B. Adhikari, A. Kraemer, J. Weckesser, N. Berner, L.-M. Berger, M. Diebold, M. Szewczyk, D. Barsyte-Lovejoy, C. Arrowsmith, J. Gerbel, F. Loehr, V. Doetsch, M. Eilers, S. Heinzlmeir, , S. Knapp

This study designs, synthesizes, and evaluates two series of WDR5 degraders, showing that linker length and nature affect degradation efficacy.

bioRxiv · Apr 12, 2021 · PreprintCancer Biology

p63 sets the threshold for induction of apoptosis using a kinetically encoded ‘doorbell-like’ mechanism

J. Gebel, M. Tuppi, A. Chaikuad, K. Hoette, L. Schulz, F. Loehr, N. Gutfreund, F. Finke, M. Schroeder, E. Henrich, J. Mezhyrova, R. Lehnert, F. Pampaloni, G. Hummer, E. H. K. Stelzer, , V. Doetsch

The paper shows that TAp63 uses a slow third phosphorylation step to set a threshold for apoptosis induction in response to DNA damage.

bioRxiv · Jun 24, 2019 · PreprintBiochemistry

Structural and Functional analysis of the GABARAP Interaction Motif (GIM).

V. V. Rogov, A. Stolz, A. C. Ravicahandran, A. Law, H. Suzuki, A. Kniss, D. O. Rios-Szwed, F. Loehr, S. Wakatsuki, V. Doetsch, I. Dikic, R. C. J. Dobson, D. McEwan

The paper identifies a GABARAP-specific interaction motif (GIM) and demonstrates its selectivity over LC3 using biophysical and structural analyses.

The EMBO Reports · Aug 1, 2017Peer-reviewedBiochemistry