BiochemistryThe EMBO JournalPeer-reviewed
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation
L. A. Gruijs da Silva, F. Simonetti, S. Hutten…·D. Dormann
This study shows that hyperphosphorylation of TDP-43 reduces its phase separation and aggregation, suggesting it may act as a protective mechanism against neurodegeneration.
DOI 10.15252/embj.2021108443