Destabilization of neuromuscular junctions and deregulation of activity-dependent signalling pathways in Myotonic Dystrophy type I
D. Falcetta, S. Quirim, I. Cocchiararo, M. Cornut, M. Theodore, A. Stiefvater, S. Lin, L. Tintignac, R. Ivanek, J. Kinter, M. A. Ruegg, M. Sinnreich, P. Castets
This study investigates NMJ destabilization and activity-dependent signaling deregulation in DM1 mouse models, identifying CaMKII and HDAC4 as key factors in synaptic gene expression and muscle dysfunction.
bioRxiv · Mar 8, 2023 · PreprintPhysiology