Author

D. Fass

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:deconvolution· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

G. Javitt· 2 shared N. Reznik· 2 shared N. Yeshaya· 2 shared T. Ilani· 2 shared A. D. Gallo· 1 shared A. M. Jaramillo· 1 shared A. Noronha· 1 shared A. Tennenhouse· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

G. Javitt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Reliable energy-based antibody humanization and stabilization

A. Tennenhouse, L. Khmelnitsky, R. Khalaila, N. Yeshaya, A. Noronha, M. Lindzen, E. Makowski, I. Zaretsky, Y. Fridmann Sirkis, Y. Galon-Wolfenson, P. M. Tessier, J. Abramson, Y. Yarden, D. Fass, S. J. Fleishman

The paper introduces CUMAb, a computational method for humanizing antibodies that improves stability and binding by systematically grafting CDRs onto human frameworks and ranking designs using Rosetta simulations.

bioRxiv · Aug 14, 2022Bioengineering

The Colon Mucosal Sialylglycome Is Redox-Regulated by the Golgi Enzyme QSOX1

T. Ilani, N. Reznik, N. Yeshaya, T. Feldman, P. Vilela, Z. Lansky, G. Javitt, M. Shemesh, O. Brenner, Y. Elkis, N. Varsano, N. Murray, P. Azadi, A. M. Jaramillo, C. M. Evans, D. Fass

This study shows that QSOX1 regulates sialylation of the colon glycome by forming disulfides in Golgi glycosyltransferases, not by catalyzing mucin crosslinking.

bioRxiv · May 3, 2022 · PreprintCell Biology

Intestinal Mucin Is a Chaperone of Multivalent Copper

N. Reznik, A. D. Gallo, K. W. Rush, G. Javitt, Y. Fridmann-Sirkis, T. Ilani, N. A. Nairner, K. Chacon, K. J. Franz, D. Fass

The paper identifies intestinal mucin MUC2 as a copper chaperone that binds and protects against copper toxicity while enabling copper uptake.

bioRxiv · Jan 2, 2022Biochemistry

3D Deconvolution Processing for STEM Cryo-Tomography

B. Waugh, S. G. Wolf, D. Fass, E. Branlund, T. Kam, J. Sedat, M. Elbaum

This paper applies deconvolution algorithms from fluorescence microscopy to improve 3D reconstruction in cryo-scanning transmission electron tomography, enhancing contrast and reducing noise in cellular structures.

bioRxiv · Aug 26, 2020Biophysics