BioengineeringbioRxiv
Reliable energy-based antibody humanization and stabilization
A. Tennenhouse, L. Khmelnitsky, R. Khalaila…·S. J. Fleishman
The paper introduces CUMAb, a computational method for humanizing antibodies that improves stability and binding by systematically grafting CDRs onto human frameworks and ranking designs using Rosetta simulations.
DOI 10.1038/s41551-023-01079-1