Author

M. Elbaum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:electronic health records· 5 Approach:deep learning· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Research Focus:deconvolution· 2

Frequent Co-Authors

J. Sedat· 4 shared D. Mullick· 3 shared M. Arigovindan· 3 shared A. McDonald· 2 shared C. Murre· 2 shared H. Cang· 2 shared L. Leiserowitz· 2 shared N. Regev-Rudzki· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersCell Biology

J. Sedat

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Author profile →

8 papers

Recent·Most cited

Optimizing contrast in automated 4D-STEM cryo-tomography

S. Seifer, P. Kirchweger, K. M. Edel, M. Elbaum

This paper presents a workflow for 4D-STEM cryo-tomography using a segmented diode and ultra-fast detector, improving contrast through 3D deconvolution and principal component analysis.

bioRxiv · Feb 23, 2024Biophysics

Bridging the light-electron resolution gap with correlative cryo-SRRF and dual-axis cryo-STEM tomography

P. Kirchweger, D. Mullick, P. P. Sawin, S. G. Wolf, M. Elbaum

The paper introduces cryo-SRRF and deconvolved dual-axis CSTET to bridge the light-electron resolution gap for 3D cellular structures.

bioRxiv · Nov 19, 2022Cell Biology

Polar Crystal Habit and 3D Electron Diffraction Reveal the Malaria Pigment Hemozoin as a Selective Mixture of Centrosymmetric and Chiral Stereoisomers

P. B. Klar, D. Waterman, T. Gruene, D. Mullick, Y. Song, J. B. Gilchrist, C. D. Owen, W. Wen, I. Biran, L. Houben, N. Regev-Rudzki, R. Dzikowski, L. Palatinus, P. Zhang, L. Leiserowitz, M. Elbaum

The paper determines the structure of hemozoin, revealing it as a mixture of centrosymmetric and chiral stereoisomers using electron diffraction and modeling.

bioRxiv · Sep 15, 2022Microbiology

Diffraction contrast in cryo-scanning transmission electron tomography reveals the boundary of hemozoin crystals in situ

D. Mullick, K. Rechav, L. Leiserowitz, R. Dzikowski, N. Regev-Rudzki, M. Elbaum

This study uses cryo-scanning transmission electron tomography to show hemozoin crystals in malaria parasites lack a surrounding lipid layer, providing insights into drug mechanisms.

bioRxiv · May 13, 2022Biophysics

A Proposed Unified Mitotic Chromosome Architecture

J. Sedat, A. McDonald, H. G. Kasler, E. Verdin, H. Cang, M. Arigovindan, C. Murre, M. Elbaum

The paper proposes a unified molecular architecture for human Chromosome 10 throughout the mitotic cycle, based on interphase structure and validated by digital PCR.

bioRxiv · Oct 14, 2021Cell Biology

A Proposed Unified Interphase Nucleus Chromosome Structure: Preliminary Preponderance of Evidence

J. Sedat, A. McDonald, H. Cang, J. S. Lucas, M. Arigovindan, Z. Kam, C. Murre, M. Elbaum

The paper proposes a unified interphase nucleus chromosome structure based on cryo-electron tomography, suggesting a coiled 'Slinky' architecture that explains various chromosome structures.

bioRxiv · Oct 8, 2021Cell Biology

Entropy Regularized Deconvolution of Cellular Cryo-Transmission Electron Tomograms

M. Croxford, M. Elbaum, M. Arigovindan, Z. Kam, D. A. Agard, E. Villa, J. Sedat

The paper applies entropy regularized deconvolution to cryo-ET data to improve resolution and reduce noise, assessing results via Fourier analysis and subtomogram analysis.

bioRxiv · Apr 26, 2021 · PreprintBiophysics

3D Deconvolution Processing for STEM Cryo-Tomography

B. Waugh, S. G. Wolf, D. Fass, E. Branlund, T. Kam, J. Sedat, M. Elbaum

This paper applies deconvolution algorithms from fluorescence microscopy to improve 3D reconstruction in cryo-scanning transmission electron tomography, enhancing contrast and reducing noise in cellular structures.

bioRxiv · Aug 26, 2020Biophysics