Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
J. V. Li, C. A. Ng, D. Cheng, M. Yao, Y. Guo, Z.-Y. Yu, Y. Ramaswamy, L. A. Ju, P. W. Kuchel, M. P. Feneley, D. Fatkin, C. D. Cox
The paper shows that N-linked glycosylation in Piezo1 channels is essential for plasma membrane trafficking and that mutations affecting this process are linked to disease.
bioRxiv · Nov 30, 2020Biophysics