Highly multiplexed quantitative phosphosite assay for biology and preclinical studies
H. Keshishian, E. R. McDonald, R. Melanson, D. A. Porter, F. Mundth, K. Krug, L. Wallace, D. Forestier, B. Rabasha, S. E. Marlow, J. Jane-Valbuena, E. Todres, H. Specht, J. Golji, E. Kuhn, , S. A. Carr
The paper introduces SigPath, a mass spectrometry assay that quantifies 284 phosphosites across 200 phosphoproteins, revealing new insights into phospho-signaling in cancer models and human tumors.
bioRxiv · Dec 8, 2020Cancer Biology