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5 papers
Recent·Most cited
M. Gentili, B. Liu, M. Papanastasiou, D. Dele-Oni, M. A. Schwartz, R. J. Carlson, A. Al'Khafaji, K. Krug, A. Brown, J. G. Doench, S. A. Carr, N. Hacohen
The paper identifies an ESCRT complex that degrades STING to suppress its signaling, showing its role in maintaining immune homeostasis.
bioRxiv · Sep 22, 2022 · PreprintImmunology
H. Keshishian, E. R. McDonald, R. Melanson, D. A. Porter, F. Mundth, K. Krug, L. Wallace, D. Forestier, B. Rabasha, S. E. Marlow, J. Jane-Valbuena, E. Todres, H. Specht, J. Golji, E. Kuhn, , S. A. Carr
The paper introduces SigPath, a mass spectrometry assay that quantifies 284 phosphosites across 200 phosphoproteins, revealing new insights into phospho-signaling in cancer models and human tumors.
bioRxiv · Dec 8, 2020Cancer Biology
J. R. Prensner, O. M. Enache, V. Luria, K. Krug, K. R. Clauser, J. M. Dempster, A. Karger, L. Wang, K. Stumbraite, V. M. Wang, G. Botta, N. J. Lyons, A. Goodale, Z. Kalani, B. Fritchman, , T. R. Golub
The paper identifies non-canonical open reading frames (ORFs) that encode functional proteins essential for cancer cell survival, with one example, GREP1, showing preferential essentiality in breast cancer.
bioRxiv · Mar 10, 2020 · PreprintCancer Biology
S. Satpathy, E. J. Jaehnig, K. Krug, B.-J. Kim, A. B. Saltzman, D. Chan, K. R. Holloway, M. Anurag, C. Huang, P. Singh, A. Gao, N. Namai, Y. Dou, B. Wen, S. Vasaikar, , M. J. Ellis
This study develops microscaled proteogenomic methods for cancer analysis, showing treatment response and resistance mechanisms in ERBB2-positive breast cancers.
bioRxiv · Oct 9, 2019Cancer Biology
Z. Xia, G. Arias-Gil, M. Deckert, M. Vollmer, A. Curran, R. Herrera-Molina, M. Brosch, K. Krug, B. Schmidt, F. W. Ohl, M. T. Lippert, K. Takagaki
This paper develops a tetrode probe with electrochemical roughening and carbon nanotube coating to enable long-term, high-quality single-unit recordings in rodent and primate brains.
bioRxiv · Aug 27, 2019 · PreprintBioengineering