H. Keshishian

The paper identifies phospho-sites in huntingtin, showing PKA phosphorylation of Ser2550 in the C-HEAT domain accelerates its degradation.

The paper improves HLA-peptidome coverage using optimized liquid and gas phase fractionation methods, enabling detection of more peptides from limited clinical tissue samples.

This study maps direct RNA-protein interactions of SARS-CoV-2 RNA in infected human cells using RAP-MS, identifying host factors, regulators, and potential drug targets involved in viral replication and host defense.

The paper introduces SigPath, a mass spectrometry assay that quantifies 284 phosphosites across 200 phosphoproteins, revealing new insights into phospho-signaling in cancer models and human tumors.

The paper identifies thousands of novel unannotated proteins in cancer that contribute to the MHC I immunopeptidome, expanding potential targets for immunotherapy.

This study identifies LepA as a conserved GTPase that enhances the synthesis of mycobacterial porins, affecting drug tolerance and membrane permeability.