Cell BiologybioRxiv
Surface topography is a context-dependent activator of TGF-β signaling in mesenchymal stem cells
S. Vermeulen, N. Roumans, F. Honig…·J. de Boer
The paper shows that surface topography enhances TGF-β signaling in mesenchymal stem cells through Rho/ROCK/SRF and PKC pathways, leading to increased expression of TGF-β target genes.
DOI 10.1016/j.biomaterials.2020.120331