Mitophagy antagonism by Zika virus reveals Ajuba as a regulator of PINK1-Parkin signaling, PKR-dependent inflammation, and viral invasion of tissues.
S. S. Ponia, S. J. Robertson, K. L. McNally, G. L. Sturdevant, M. Lewis, F. Jessop, C. Bosio, D. Gallegos, A. Hay, C. Schwartz, R. Rosenke, G. Saturday, C. Martens, S. M. Best
This study shows ZIKV NS5 inhibits mitophagy by blocking Ajuba's role in PINK1-Parkin signaling, leading to increased inflammation and viral spread.
bioRxiv · Jan 29, 2021 · PreprintMicrobiology