C. Bosio

Lipin-1 restrains macrophage lipid synthesis to promote inflammation resolution.

This study shows that lipin-1 limits macrophage lipid synthesis, which supports inflammation resolution by enhancing efferocytosis.

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques

The combination of molnupiravir and nirmatrelvir inhibits SARS-CoV-2 replication and shedding more effectively than individual treatments in the rhesus macaque model.

Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques

This study compares immune dynamics in young and old rhesus macaques infected with SARS-CoV-2, finding age-related differences in post-acute immune responses but similar acute disease outcomes.

Western diet increases COVID-19 disease severity in the Syrian hamster

This study shows that a Western diet worsens COVID-19 outcomes in Syrian hamsters by increasing weight loss, lung damage, and systemic inflammation.

Mitophagy antagonism by Zika virus reveals Ajuba as a regulator of PINK1-Parkin signaling, PKR-dependent inflammation, and viral invasion of tissues.

This study shows ZIKV NS5 inhibits mitophagy by blocking Ajuba's role in PINK1-Parkin signaling, leading to increased inflammation and viral spread.

Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

This study shows hydroxychloroquine does not reduce SARS-CoV-2 replication or improve clinical outcomes in hamsters or macaques.

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

This study shows remdesivir reduces SARS-CoV-2 viral load and lung damage in rhesus macaques when administered early in infection.

TRIM5α restricts flavivirus replication by targeting the viral protease for proteasomal degradation.

This study shows TRIM5α restricts flavivirus replication by targeting the viral protease for proteasomal degradation, with implications for human susceptibility to emerging flaviviruses.